How It Works

Drinking HOTSHOT stimulates sensory neurons in the mouth, esophagus, and stomach.

Stimulated neurons send impulses to the spinal cord.

These impulses overpower and inhibit repetitive signals coming to and from the cramped muscle.

This stops repetitive signals and prevents and/or treats the cramp.

Our Scientific Team


Roderick MacKinnon, M.D.

Professor, Rockefeller and HHMI,
Nobel Prize 2003

Bruce Bean, Ph.D.

Harvard Medical School

Sports Advisory Board

Bob Murray, Ph.D. FACSM

Managing Principal,
Sports Science Insights

Larry Kenney, Ph.D.

Penn State University

Chad Prusmack, M.D.

Chief of Neurosurgery,
Rocky Mountain Spine Clinic,
Neurosurgery Consultant,
Denver Broncos

Scientific Advisory Board

HOTSHOT’s inventors, Dr. Rod MacKinnon and Dr. Bruce Bean, lead a renowned Scientific Advisory Board that guides HOTSHOT and its parent company Flex-Pharma, a Boston-based biotechnology company co-founded by
Dr. MacKinnon.

Alfred Sandrock, M.D.

Group Senior Vice President of Development Sciences and Chief Medical Officer, Biogen

Roger D. Tung, Ph.D.

President and Chief Executive Officer, Concert Pharmaceuticals

Christopher T. Walsh, Ph.D.

Professor Emeritus, Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

John Winkelman, M.D., Ph.D.

Associate Professor of Psychiatry, Harvard Medical School

Ready to try HOTSHOT?

Get 50% off your first 6-pack!