Hotshot helps restore control by optimizing the way your muscles and nerves work together so that you can
push harder, train longer, and finish stronger.

How It Works

Drinking HOTSHOT stimulates sensory neurons in the mouth, esophagus, and stomach.

Stimulated neurons send impulses to the spinal cord.

These impulses overpower and inhibit repetitive signals coming to and from the cramped muscle.

This stops repetitive signals and prevents and/or treats the cramp.


The research

HOTSHOT’s carefully calibrated, proprietary formulation was developed after five years of scientific research. Proven to work by researchers at Penn State University and in field studies, HOTSHOT has been shown to significantly reduce muscle-cramp intensity and duration compared to placebo. HOTSHOT has also been associated with lower post-cramp muscle soreness.

Our scientists, in partnership with leading sports science institutes, are continuing to study the benefits of HOTSHOT and how it impacts an athlete’s Neuro Muscular Performance.

Field Study:
Hotshot’s Effect on Cramp
Prevalence During Workout

Field Study:
Hotshot’s Effect on Cramp
Prevalence Post-Workout

Get HOTSHOT for $3.95 / bottle with a HOTSHOT subscription plan


Our Scientific Team


Roderick MacKinnon, M.D.

Professor, Rockefeller and HHMI,
Nobel Prize 2003

Bruce Bean, Ph.D.

Harvard Medical School

Sports Advisory Board

Bob Murray, Ph.D. FACSM

Managing Principal,
Sports Science Insights

Larry Kenney, Ph.D.

Penn State University

Chad Prusmack, M.D.

Chief of Neurosurgery,
Rocky Mountain Spine Clinic,
Neurosurgery Consultant,
Denver Broncos

Scientific Advisory Board

HOTSHOT’s inventors, Dr. Rod MacKinnon and Dr. Bruce Bean, lead a renowned Scientific Advisory Board that guides HOTSHOT and its parent company Flex-Pharma, a Boston-based biotechnology company co-founded by
Dr. MacKinnon.

Alfred Sandrock, M.D.

Group Senior Vice President of Development Sciences and Chief Medical Officer, Biogen

Roger D. Tung, Ph.D.

President and Chief Executive Officer, Concert Pharmaceuticals

Christopher T. Walsh, Ph.D.

Professor Emeritus, Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

John Winkelman, M.D., Ph.D.

Associate Professor of Psychiatry, Harvard Medical School

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