INVENTED BY A NOBEL-PRIZE WINNING NEUROSCIENTIST/ENDURANCE ATHLETE AND HIS FRIEND, A NEUROBIOLOGY PROFESSOR AT HARVARD

Off the coast of Cape Cod,

Dr. Rod MacKinnon and his friend, Dr. Bruce Bean, were deep sea kayaking in the winter when they were both seized with life-threatening muscle cramps. They experienced such debilitating pain that neither could steady their kayaks.

While they survived the excruciating moment, it flipped the switch on their curiosity – why do we cramp? What is the cause? What is the cure?

Over the next five years, Rod and Bruce worked to unravel the mystery, and discovered this surprising truth: when it comes to preventing muscle cramps, it’s not about treating the muscle, it’s about treating the nerve.

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Our Scientific Team

Inventors

Roderick MacKinnon, M.D.

Co-Inventor,
Professor, Rockefeller and HHMI,
Nobel Prize 2003

Bruce Bean, Ph.D.

Co-Inventor,
Professor,
Harvard Medical School

Sports Advisory Board

Bob Murray, Ph.D. FACSM

Managing Principal,
Sports Science Insights

Larry Kenney, Ph.D.

Professor,
Penn State University

Chad Prusmack, M.D.

Chief of Neurosurgery,
Rocky Mountain Spine Clinic,
Neurosurgery Consultant,
Denver Broncos

Scientific Advisory Board

HOTSHOT’s inventors, Dr. Rod MacKinnon and Dr. Bruce Bean, lead a renowned Scientific Advisory Board that guides HOTSHOT and its parent company Flex-Pharma, a Boston-based biotechnology company co-founded by
Dr. MacKinnon.

Alfred Sandrock, M.D.

Group Senior Vice President of Development Sciences and Chief Medical Officer, Biogen

Roger D. Tung, Ph.D.

President and Chief Executive Officer, Concert Pharmaceuticals

Christopher T. Walsh, Ph.D.

Professor Emeritus, Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

John Winkelman, M.D., Ph.D.

Associate Professor of Psychiatry, Harvard Medical School

Our Elite Athletes

"I feel HOTSHOT has really enhanced the performance of my key intensity sessions.”
"I feel HOTSHOT has really enhanced the performance of my key intensity sessions.”
Craig "Crowie" Alexander 3X IRONMAN® Triathlon World Champion
"Knowing that HOTSHOT is organic, all natural ingredients, that’s a key factor for me.”
"Knowing that HOTSHOT is organic, all natural ingredients, that’s a key factor for me.”
Shalane Flanagan Olympic & Champion Marathoner
“There is no doubt in my mind that HOTSHOT contributed enormously to my best-ever year of racing in 2016.”
“There is no doubt in my mind that HOTSHOT contributed enormously to my best-ever year of racing in 2016.”
Tim Reed Reigning IRONMAN® 70.3 Champion
"With HOTSHOT, my stride and my form feel perfect, and I feel very efficient and strong.”
"With HOTSHOT, my stride and my form feel perfect, and I feel very efficient and strong.”
Evan Jager Olympic Silver Medalist, Steeplechase
“I love HOTSHOT's spicy taste and without cramps my body is able to jumpstart the recovery process."
“I love HOTSHOT's spicy taste and without cramps my body is able to jumpstart the recovery process."
James Develin 2x Champion Pro Fullback
"I love the way HOTSHOT makes me feel and that it removes the stress of cramps.”
"I love the way HOTSHOT makes me feel and that it removes the stress of cramps.”
Amy Cragg Olympic & Champion Marathoner
"Thanks HOTSHOT for keeping me cramp-free.”
"Thanks HOTSHOT for keeping me cramp-free.”
Colleen Quigley Olympian, Steeplechase
"I’m eager for the summer season to begin because I know that I have a huge advantage with HOTSHOT. So many people fear cramps, and I don’t worry about them anymore!"
"I’m eager for the summer season to begin because I know that I have a huge advantage with HOTSHOT. So many people fear cramps, and I don’t worry about them anymore!"
CLARE GALLAGHER Ultrarunner & Leadville Champion

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